Researchers have developed a microscope using an extremely powerful laser to make previously invisible cellular structures easier to see, dramatically improving image clarity and allowing examination of small proteins that conventional electron microscopes struggle to capture. It could eventually reveal how tiny molecular machines interact inside cells; the technology remains at the research stage.
Findings suggest that Earth's gravity and magnetism have unexpected effects on the human genome and mitochondria. These discoveries could potentially have implications for space travel and for treating neurodegenerative diseases.
A natural compound extracted from a medicinal plant showed promise against rheumatoid arthritis in rats, reducing joint swelling, protecting cartilage and calming immune responses behind chronic inflammation. Scientists found it works by targeting a specific protein and restoring balance to fatty acid metabolism. The evidence is from animal models and has not been validated in humans.
In a clinical trial involving 63 patients, researchers found that ultrasound-guided hydrodissection provided longer-lasting improvements in pain and hand function compared to traditional steroid injections. This simple, steroid-free procedure could potentially offer lasting relief for people with carpal tunnel syndrome, helping them avoid surgery.
According to Nature Biotechnology, Recordanelles can capture transient gene expression in single human cells. No further details are provided in this item.
A new study found that excess RNA, including normally essential messenger RNA (mRNA), can directly disrupt mitochondria—the cell's energy-producing structures—without relying on the immune system. Researchers say the finding could help explain how viral infections and certain aging-related diseases damage cells.
Roivant reported positive trials for an immune drug in the eye disease non-infectious uveitis, and the company says the drug could be headed to a new market.
Scientists converted blood cells from an 80-year-old into neural stem cells with a molecular age of under 20, effectively reversing more than 60 years of cellular aging in the laboratory. The researchers say the discovery offers a new way to study how cells become younger and could help researchers better understand age-related diseases such as Alzheimer's; the work remains at the laboratory stage.
Mark Cuban's Cost Plus Drugs says it can reduce manufacturing costs for custom rare disease drugs and n-of-1 gene therapies, aiming to open up the rare disease treatment market.
German biotech Immatics is at a pivotal moment after a quarter century of work. The company is currently awaiting the Phase 3 results for its lead candidate drug targeting melanoma.
Guinea-Bissau police said hepatitis B vaccine doses were taken as part of an investigation into an office raid involving allies of RFK Jr., whose team was reported to be planning an "unethical" vaccine trial on babies.
Researchers using advanced imaging found that statins can attach to a key protein in muscle cells and force open a channel that normally regulates calcium flow, causing continuous calcium leakage that may damage muscle tissue. The finding is presented as an explanation for why statins can sometimes cause muscle pain, weakness, or severe muscle damage; the context does not state whether this has been verified in humans.
Scientists suggest the aging brain may shift from remembering details to understanding the bigger picture rather than simply losing abilities, a change they propose could be an evolutionary adaptation helping older adults develop wisdom and share decades of knowledge with younger generations.
Scientists report a promising approach to protecting the brain from Alzheimer's-related damage by blocking immune cells that contribute to neuron destruction. In mice, the treatment preserved roughly 40% more tissue in memory centers and improved memory, even without removing harmful tau buildup.
A clinical trial suggests daily vitamin C could improve survival in people with precancerous blood disorders and early-stage blood cancers. Patients receiving the supplement had fewer adverse events and showed a promising survival advantage, though the finding remains at the trial stage.
Researchers report that recurring arthritis triggered by cancer immunotherapy may be driven by immune cells that remember previous attacks and return in a more aggressive state. The findings could pave the way for treatments that prevent painful flare-ups while preserving the immune system's ability to fight cancer.
Nature Medicine published an author correction concerning a phase 1 trial paper on the FcRH5×CD3 bispecific antibody cevostamab in relapsed or refractory multiple myeloma. The item provides no details on what was corrected.